High-Throughput Lead Optimization in Drug Discovery by Tushar Kshirsagar

By Tushar Kshirsagar

A unmarried resource on Parallel Synthesis for Lead Optimization

The finish of the former millennium observed an explosion within the program of parallel synthesis innovations for making compounds for high-throughput screening. through the years, it grew to become transparent that extra concept within the layout part of library improvement is critical to generate prime quality hits. extra lately, using parallel synthesis options has shifted to purposes past screening collections. Exploring the nuances of this expertise, High-Throughput Lead Optimization in Drug Discovery describes the applying of parallel synthesis to guide optimization and the layout and synthesis of special libraries.

Examine Case stories that disguise a number diverse organic Targets

Featuring real-world examples and contributions from famous scientists, the ebook explores the shift to accomplishing parallel lead optimization in-house whereas outsourcing many of the screening libraries synthesis. It comprises greater than 15 case experiences that surround quite a number organic ambitions for software in several healing components. The textual content includes examples of sturdy and solution-phase ideas for the synthesis of directed libraries. The bankruptcy authors clarify the layout ideas they used to direct the alternative of templates and variety parts.

Speed Up Drug Discovery and the Hit-to-Lead Process

Focusing at the software of combinatorial chemistry to medicinal chemistry, this quantity compiles a sequence of optimization initiatives that provide you with a photo of successes and demanding situations within the use of parallel synthesis for lead optimization. It explores how this expertise, while utilized to library layout, can accelerate drug discovery.

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